Montelukast
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Q: Validated HPLC analysis of montelukast and levocetrizine in pharmaceutical formulation and bilogical sample.?
Montelukast is a leukotriene inhibitor used to prevent asthma attacks in adults and children as young as 12 months old. Levocetirizine, a third generation non-sedative antihistamine is also used along with Montelukast in persistent allergic asthma. The combination of these two can be determined in pharmaceutical formulations and biologiacal samples using HPLC analysis method.
A: Great!
Q: Why is it important that Singulair (montelukast Na) be in ionized form at the pH of blood?
Please provide a reputable source and explanation please!
A: Large organic molecules tend to be insoluble in water (like dissolves like). For this molecule to be soluble, you must try to make it as hydrophilic (i.e. water loving) as possible. This is usually accomplished by using an sodium, or potassium salt, or in other molecules, by acidifying or alkalinizing the drug.
In short, if it wasn’t a salt, it would not be soluble enough in the plasma (which is mostly water) and could not circulate to the target regions.
Damn, you went and acutally made me use my organic chem knowledge. 
Q: is montelukast drug is useful to prevent asthma permanently for children for age 5?
5 ys old my son having severe congestion and doctors prescribes montelukast for 6 months is that ok pls get bck to me
A: Andy is mostly right. Montelukast also know as Singualir is indicated by the FDA for children as young as 2 years old. This dose is in powder form. Montelukast is an anti Leukotriene more specifically, it is a Leukotriene modifier not an antihistamine. In fact it can be taken with antihistamines.
It is indicated for the prevention and treatment of seasonal allergies and asthma.
For a 5 year old that has congestion, yes It is fine unless he has side effects or is allergic to the medication. Did the doctor prescribe any other medications? I am not a doctor but I would have prescribed a decongestant too.
Q: 3yr daughter suffered with asthma for the last 2yrs has been given various inhalers and montelukast tablets?
Daughter has been on seratide all summer with no symptoms however the start of this month her symptoms have come back just the same so dont understand what is the point of taking the inhaler if the symptoms still appear in the winter just the same?
A: does she take her meds as prescribed? MONTELUKAST (Singulair®) helps to reduce asthma symptoms (coughing, wheezing, shortness of breath, or chest tightness) and control your asthma. It does not provide instant relief and cannot be used to treat a sudden asthma attack. It works only when used on a regular basis to help reduce inflammation and prevent asthma attacks. Montelukast is effective in adults and children. This drug is also helpful in improving seasonal allergies, like hay fever. Generic montelukast tablets or chewable tablets are not yet available. she should have something like an Albuterol inhaler too and a rescue inhaler for emergencies. decadron is a steriod that helps too. cold weather exacerbates asthma as does ragweed that is produced this time of year. even with drugs and inhalers, she’ll have “episodes”. most hold asthma at bay but she can have break through episodes. talk to your doctor about it and see if he can make any suggestions or med changes. kids change so quickly that meds that worked one month can have no effect the next since their body chemstries change so rapidily. the good news is that the chance of her growing out of it are excellent since she’s so young.
Q: My doctor prescribed me “montelukast” but the pharmacist dispensed “montelukast sodium”. Are these 2 thesame?
Should I return the montelukast sodium to the drugstore or is it okay I just use it?
A: Montelukast (Brand name Singulair) is used for the treatment of asthma. It works by stabilizing the mast cells which are thought to be the major products in the causing of inflammation and constriction of the airways.
Montelukast is the active ingredient and sodium is the “salt” that it is attached to. The reason for binding it to the sodium is for the purpose of allowing the drug to easily penetrate the cell, thus, producing a better effect.
Most drugs are bound to “salts” such as sodium and potassium. Both these have good penetrative properties.
In short, the drug you have been dispensed it correct.
The Pharmacist.
Q: What happens if you double dose on Singulair (Montelukast)? It says DO NOT TAKE MORE THEN 1 IN 24 HOURS.?
How dangerous is it? The dosage is 10mg. This was several days ago so I probably only took one, but what happens if I or someone DOES take 20 mg of Singulair when prescribed 10mg? What would happen?
A: The danger is none to slim … most overdoses that have been documented exceeded 1000 mg … so .. 20 mg will probably show little effect or may enhance the side effects that you feel .. if you have any ….
Q: Can Montelukast be given in skin allergies?
A: Like to treat skin allergies? No. It is for allergic rhinitis or asthma.
Q: Why montelukast must taken in the evening?
A: Singulair (Montelukast) should be taken in the evenings because one of it’s major side effects is fatigue. It’s much easier to deal with at night when you’re about to go to bed anyway, rather than trying to battle it during the day.
Also, the bronchodilation effects (opening of the airways) prevents asthma attacks and helps promote a more restful sleep, because you can breathe easier.
Q: What happens if I accidentally double dosed on Singulair (Montelukast)? 10mg?
I’m worried something is going to happen. I don’t think I did, I’m not usually forgetful… but just in case.
A: You will be fine. Just try not to do it.
Q: why montelukast is recomended at night for asthma and at morning for allergic rhinitis?
A: singulair is recommended at night for asthma because during the clinical trial and other studies for singulair, it was noted that the night time dosing decreased the number of wakening due to asthma symptoms ( coughing, wheezing). it is recommended during the morning because it inhibits the release of substances in the body that are released when we come into contact with the particular allergen. therefore you will have protection against the allgeric reaction for the full day.
Q: Is it ok if i chew montelukast kastair 10mg?
Non-chewable
A: Singulair (montelukast) makes both standard (non-chewable) and chewable tablets. If your tablet is labeled as the chewable kind, then yes, it’s okay to chew it. Otherwise, you should swallow the tablet whole.
Q: how long probably shoud i take montelukast? Isn’t ok to take it for 1 month?
A: It could take weeks to work. Why are you taking it? If its for daily control of asthma and allergies, then you need to take it everyday.
Singulair is now approved for exercise induced asthma. You can take it as needed. This article explains…
http://health.msn.com/centers/asthma/articlepage.aspx?cp-documentid=100161506
Q: Faktu & Montelukast?
I was recently prescribed Faktu ointment to control my anal itching. My question is, how should I apply this? It came with a tube (which I am pressuming should be inserted into the anal cavity) which I initially did not use due to my hesitation in having anything inserted into my butt. So… i opted to use it as a cream but when the itching did not stop, I took the risk of finally using the tube applicator however, the itching still did not stop. Am I appying it the right way?
In relation to my first question, I’ve had this anal itching for about a month already and have gone through a fecal test which came out negative. Could this itching be a side effect of my long term use of Montelukast (I was prescribed this tablet to control my asthma)? I’ve been taking Montelukast for about 6-7 months already.
Heelllpppppp!!!!!!! 
A: FAKTU comes in two forms – ointment and suppository. The ointment as its name implies will be applied just like any other ointment – using an applicator tube. While the suppository form is to be inserted in the rectum – it is usually supplied with a rectal applicator to facilitate insertion.
Faktu has combined effects to arrest rectal bleeding, guard against infection, relieve pain irritation and inflammation and promote wound healing in any case of hemorrhoids.
Though itching is one of the possible side effects of Montelukast (in fact it is a serious side effect), I doubt if it will cause just a local anal itching. But we can give a possibility on that as well.
Try doing sitz bath – place tolerable warm water in a basin and sit for about 15-20 minutes or longer as desired, see if it helps somehow.
If itching persists, be sure it is not some kind of yeast or fungal infection. Try to discuss it with your doctor – you may need some topical cream containing hydrocortisone or the like to relieve your itching. Most importantly, what causes the itching needs to be identified.
Q: can i use montelukast incombination with steroids?
A: You should be asking this question of your doctor. It would also be ok to ask your pharmacist.
Q: Is COPD an indication for montelukast?
A: nope, in my opinion (no current FDA indication, either)
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